Bradley Cairns is interested in how chromatin structure helps regulate gene transcription. His lab purifies and characterizes large protein complexes that remodel and modify chromosomal structure. The lab also investigates how chromatin regulates RNA Pol III transcription, and noncoding RNAs methylation. A major emerging interest is germline chromatin—how genes are marked (by DNA methylation) and packaged by chromatin in sperm and eggs—to promote proper gene expression in the embryo. Dr. Cairns received his PhD from Stanford in Cell Biology and conducted postdoctoral studies at Harvard Medical School. He is now an HHMI Investigator and Chair of the Department of Oncological Sciences at the Huntsman Cancer Institute, University of Utah School of Medicine.
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